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WebAug 15, 2008 · Studies conducted in the 1970s showed that 50 mg of chlorthalidone once daily was equivalent to 50 mg of HCTZ twice daily. 5, 6 The half-life of chlorthalidone is much longer than that of HCTZ (24 ... WebApr 1, 2024 · Swallow the tablet whole. Do not break, crush, or chew it. This medicine may be taken with or without food. If you also use cholestyramine or colestipol, take these at least 4 hours after you take this medicine. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. WebChlorthalidone comes as a tablet to take by mouth. It usually is taken once a day or every other day after a meal, preferably breakfast. It is best to take this medicine in the morning to avoid going to the bathroom during the night. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any ... original farmer says see n say